Antispermatogenic effects of Nyctanthes arbortristis in male albino rats
نویسندگان
چکیده
The present is an attempt to evaluate the antispermatogenic activity of methanol extract of Nyctanthes arbortristis stem bark in male albino rats. Methanol extract of N. arbortristis stem bark was administered orally to adult male albino rats at the dose level of 100 mg/kg b.wt. for 60 days. On day 61 the rats were autopsied, the testes and accessory reproductive organs were removed and weighed. The organs were processed for biochemical estimations and histopathological observations. Sperm motility and sperm density in cauda epididymis were also assessed. The results revealed that the Nyctanthes stem bark extract treatment caused a significant decrease in weight of testes and accessory reproductive organs whereas body weight did not showed any significant change when compared to control. Sperm motility as well as sperm density reduced significantly, which resulted in total suppression of fertility. Significant reduction was also observed in biochemical estimation of testicular protein, sialic acid, glycogen and seminal vesicular fructose whereas cholesterol content of testes was increased. A marked diminution in the germ cell population was noticed. Production of spermatids declined by 64.29 %. Seminiferous tubular diameter and Leydig cell nuclear area showed notable reduction. The Sertoli cells count and its cross-sectional surface area was also significantly reduced. There was no significant alteration in the blood and serum parameters throughout the course of investigation. In conclusion Nyctanthes arbortristis methanol stem bark extract causes impairment of testicular function and affects spermatogenesis in male rats.
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